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Preventing a dangerous game of hide-and-seek in medical trials

Helen S reveals how the pharmaceutical industry hides unfavourable results from medical trials. She warns of the risks to human health, and proposes how we can make medical research more robust and trustworthy

Have you ever questioned the little pills prescribed by your doctors? I had not, until I began working on this article – and the truth is, we know less than we should about them. It is scary to think that, though these medications are supposed to heal us when we are feeling poorly, in reality, that it is not always the case.

Clinical trials are experiments or observations done for clinical research that compare the effects of one treatment with another. They may involve patients, healthy people, or both. Some are funded by pharmaceutical companies, and some are funded by the government. I will mainly focus on the phenomenon of hiding negative data in industry-funded trials.

Research done in 2005 by Evelyne Decullier, Senior Research Fellow at Hospices Civils de Lyon, compared registered trials that have failed and those that have succeeded, and which ones appear in the medical journals and academic literature. They consistently found that only half of trials are ever published and that positive results are 2.5 times more likely to be published than negative results.

Now, you might say, ‘how can those trials possibly affect me or other ordinary people?’ Well, read on…

Why this matters for your health

Lorcainide is an anti-arrhythmic heart drug and was tested in clinical trials in the 1980s. The results showed that patients given Lorcainide were far more likely to die than patients who weren’t.  But those results were not published until 10 years later, and during that time, doctors had been prescribing the drug to patients. According to Dr Ben Goldacre, director of DataLab at Oxford University, it has been estimated that more than 100,000 people who had taken Lorcainide died in America as a result. And Lorcainide is not a single case. Similar things may be happening to other clinical trials relating to drugs such as anti-depressants or cancer treatment.

The lack of transparency can also affect decisions on government spending. From 2006 to 2013, the UK government was advised to buy a drug called Tamiflu which was supposed to reduce pneumonia and death caused by influenza. The UK government went on to spend £424 million stockpiling this drug. But when the systematic reviewers tried to gather up all the trials that have been done on Tamiflu, they realised that the government had only seen a small number of the trials. They battled for years to get the trials from the drug company, and when they had finally got all of them, they found that Tamiflu was not sufficiently effective to justify that large a cost. If companies continue to withhold trials, similar expensive trials are going to be repeated, putting the volunteers, patients and doctors in danger.

Pharmaceutical companies have failed us, so what about the law? In America, it is required that medical trials held in the US need to be registered and have their results submitted within one year of the trial finishing. However, when scientists looked back at the data in 2015, they found out that only 20% of trials were submitted and reported.

Industry-funded research is not the complete villain in this situation. During these types of research, discoveries are more likely to occur (Adam, 2005; Adam, Carrier, & Wilholt, 2006; Carrier, 2004). And thanks to funding from industry, scientists are less pressured to present something that is directly linked to real‐world use, compared to public or government-funded projects (Carrier, 2011). And as we all know, new technologies all start with discoveries.

Finding remedies

Here are some suggestions from scientists for improving the current situation: to increase the transparency, to increase reproducibility and the most doable one, effective criticism (Elliott,2018). Out of these, the criterion that is the easiest to modify is to have more effective criticism. It is important to acknowledge that criticism doesn’t need always to be negative. Though the agencies that are usually responsible for evaluation can be limited by a variety of reasons, such as  understaffing or political issues, “they can get more involved in designing the safety studies performed by industry in specific cases,” suggests Philosopher of Science, Kevin Elliott. (A safety study is a study carried out after a medicine has been authorised, to obtain further information on a medicine’s safety, or to measure the effectiveness of risk-management measures.)

Luckily we have the technologies in our hands. Alpha Fold is leading the scene: it has done some amazing and accurate predictions on predicting the 3D shape of proteins, meaning scientists can facilitate the design of stable protein. It can also help to make sense of X-ray data to determine crystals structure; before Alpha Fold was invented, determining the structure of proteins to do structure-based drug design could take 3-4 years. Now they are presented in front of you in less than an hour.

Everyone is different, some people might have allergies, and some drugs might not even work for some people. To avoid these situations, technologies such as AI could make your prescription personalised to you. By analysing your DNA information sent to your pharmacy, AI would analyse the dosage and the drug suitable for you. The 3D printed “polypill” is a single pill that has all the personalised medication you need in one day in one pill, which is remarkable. 

Hopefully, now it is a little easier to understand the importance of transparency in clinical testing. Trial results were never just numbers – they are directly linked to the lives of millions. Pharmaceutical companies were not simply hiding data – they were hiding the deaths of the volunteers and patients, and the money of families wasted on more expensive but less effective treatments. There must be, without doubt, serious consequences if companies don’t follow regulations.  I believe there will be hope if the scientists use technology effectively and if a better research environment is created for future generations.

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Bringing the real world in: using current affairs to shape A Level Economics.

Stack of newspapers

This article focusses on how we incorporate current affairs into our teaching of A Level Economics. It is written by Richard Finch – Head of Economics at Wimbledon High School.

One great aspect of teaching Economics at A Level is that we can relate the topics on the specification to real world events. We run weekly news article review sessions with all our classes to build their understanding of contemporary issues in Economics and strengthen their ability to apply fundamental concepts and theories to these real-world events. For many pupils, beyond improving their chance of achieving a top grade and boosting their ability to critically analyse articles, this process builds their confidence to engage in debate and can be very empowering.

However, it often it is a challenge to stimulate that initial interest in current affairs, particularly stories related to the Economy.  However, in recent years we have made significant progress on this issue.

At the start of the course, each week, we ask our Year 12 students to find two articles, one related to microeconomics (individual industries and business) and one to macroeconomics (the entire economy). These articles can be from any publication and on any subject that interests them.

The pupils post a brief summary of the article on our OneNote system along with their general reflections. We keep the brief very flexible at this stage and the emphasis is very much on exploring what interests them. We as teachers then review the articles and post some leading questions for each. This encourages the pupils to reflect on what they’ve read and think about where their research might lead them.

The pupils have time to prepare their response to these questions prior to the lesson. During the lesson the teacher will project the summary on the screen and the pupil then presents to the class. The teacher chooses three pupils from the class who have demonstrated clear analysis or whose topic area was addressed by many students in the class. We have found that celebrating work in this way creates an element of friendly competition and encourages others to engage.

Interestingly, although we do not limit the topics at this stage, the pupils tend to gravitate towards similar articles and as they source their information from different publications these presentations often lead to enthusiastic class debate. This also serves as a great way to break the ice with a new Year 12 class.  

Through our questioning we encourage pupils to pursue additional articles on the same topic. Over weeks the pupils start to develop expertise in certain topic areas and having that deeper understanding builds their confidence. As they become more familiar with the jargon used in Economics they start to source articles from more challenging publications.   

As the course progresses we start to encourage the pupils to apply the fundamental concepts and theories we cover in class to these real-world examples. We want our pupils to use this “Economics Toolkit” to deepen their analysis and understanding.

For example, here a pupil has applied their knowledge of Income Elasticity of Demand (the responsiveness of demand to a change in income) to the demand for Fortnum & Mason products to assess the extent to which these products can be described as luxury items and the implications of a change in national income on this particular organisation and the wider economy.

The term “luxury good” is used commonly in society but Economics pupils develop an understanding of what this term actually means and how it can be calibrated. This gives them a clearer understanding of the likely implications of a national rise in income on this market. They begin to make links at this stage between different concepts and ask broader questions, beyond the focus of that article. We continue to encourage them to explore and connect topic areas through our questioning and through class debate.

The pupils start to develop real expertise at this stage and we find ourselves referring to our “in-house retail expert” for example during class discussion. Being the authority on an issue is incredibly empowering for the pupils and builds their engagement and enthusiasm for the subject. The ultimate aim of this initiative is to encourage our pupils to use their voices and speak with authority on this traditionally male dominated subject.

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How are organoids going to change biomedical research?

Microscope

Kate in Year 13 explores how organoids are going to contribute to biomedical research. 

At the moment, biomedical research is almost exclusively carried out in animal models. Although this has led to a better understanding of many fundamental biological processes, it has left gaps in our understanding of human specific development. In addition to this, the variability of human individuals is in sharp contrast to inbred animal models, leading to a deficiency in our knowledge about population diversity.

These limitations have forced scientists to invent a new way of looking at and understanding how the human body works; their conclusions were organoids.

An Organoid (Wikipedia)

Organoids are a miniaturised and simplified version of an organ produced in vitro in 3D which shows realistic micro-anatomy. They originate from renewable tissue sources that self-organise in culture to acquire in vivo-like organ complexity. There are potentially as many types of organoids as there are different tissues and organs in the body. This provides many opportunities such as allowing scientists to study mechanisms of disease acting within human tissues, generating knowledge applicable to preclinical studies as well as being able to offer the possibility of studying human tissues at the same if not higher level of scientific scrutiny, reproducibility and depth of analysis that has been possible only with nonhuman model organisms.

Organoids are going to revolutionise drug discovery and accelerate the process of bringing much needed drugs to reality. Nowadays, the process averages around 20 years from conception to reality. This is a lengthy process mainly due to the fact that the pharmaceutical industry has relied on animal models and human cell lines that have little resemblance to normal or diseased tissue – possibly one of the reasons behind the high failure rate of clinical trials adding to the high cost of drug discovery – an average of $2 billion for each new drug that reaches the pharmacy.

Organoids can help this development by using human cells instead of animal cells due to the improved compatibility, making it quicker and more efficient. Organoids are also able to provide a better understanding of human development.

Organoid graph
Above: Uses of organoids from https://blog.crownbio.com/key-organoid-applications

The human brain, especially the neocortex (which is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, spatial reasoning and language), has evolved to be disproportionally larger compared with that of other species. A better understanding of this species-dependant difference through brain organoids will help us gain more knowledge about the mechanisms that make humans unique, and may aid the translation of findings made in animal models into therapeutic strategies answering the question what makes humans human.

Organoids are the future of biomedical research providing the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with non-human model organisms. Resembling the complexity of the actual tissue or organ, patient derived human organoid studies will accelerate medical research and generate knowledge about human development which is going to dramatically change the way we are going to study biology in the future.

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Is authentic research, where young scientists have complete free rein, really possible at school?

Dr Clare Roper, Director of Science, Technology and Engineering at WHS, looks at how advances in information technology have removed the barriers that often limit the scope for school students to embark on their own innovative authentic scientific research.

I was sitting in a lecture at Oxford University about 18 months ago when it suddenly became clear to me that the factor most often restricting school students from undertaking their own authentic research had evaporated and was no longer an issue.

Classroom science experiments commonly involve replicating known scientific phenomena to backup discoveries that are well documented in the scientific literature. Unfortunately, quite often we cannot even so much as replicate the data from a science textbook in a school laboratory because the data collection is too complex. Instead, we might explore the scientific process taken by a research group as we unpack a beautiful classic experiment and marvel at their discovery and how it has shaped our understanding of scientific concepts . A personal favourite is the magically simple experiment of Meselson and Stahl which elucidated how exact copies of DNA are created each time a new cell is formed [1]. At the end of a lesson exploring their experiment, it is customary to have a look at photographs of the scientists and perhaps consider how they may have come up with their experimental design.

Meselson in lab
Above: Meselson in his lab, 1958

I often ponder whilst looking at a black and white photograph of a scientist with his unrecognisable equipment, how this person might be perceived by the students sitting in front of me in our shiny new STEAM tower. Is this what being a scientist entails? Even after removing the stereotype of the person themselves, there is the barrier of the often sophisticated machinery and the hours of patient work required to collect sufficient data to make meaningful conclusions. I have no doubt that although we can enjoy the simplicity of their experiments in class, it surely reinforces the notion that novel scientific research is something inaccessible and unattractive to many school students.

In sport, there are countless role models of young athletes competing on the world stage, with celebrated successes at their local schools. The same can be said of talented young actors, artists, musicians and even activists and politicians. But try to think of a brilliant young scientist who has gone on to become a world leader having had the opportunity to hone their skills and find their path whilst at school. The fantastic news that two leading female scientists, Emmanuelle Charpentier and Jennifer Doudna, have just been awarded the Nobel Prize in Chemistry for their work on genome editing [2] will certainly go a long way to inspiring more female scientists to dream big. However, like most leading scientists, their first taste of authentic research came after entering university and most are often only recognised much later in life.

The good news is that a growing number of passionate science teachers have teamed up with academics and a variety of institutions to provide opportunities for young scientists. Most research projects require access to expensive machinery or software that is beyond the reach of a school science department budget, and even those projects that are possible often tend to focus more on one or two aspects of the scientific process and cannot give the students carte blanche to explore their own curiosities because of time or cost constraints. Nevertheless at WHS we jumped on board and our students have benefitted hugely from projects including ORBYTS, and IRIS.

While I was in that lecture at Oxford that I suddenly realised that the missing ingredient that has recently evaporated was the need for the sophisticated machinery, and along with it, the prohibitive costs, and lengthy time required to collect data. The lecture was given by Prof Stephen Roberts, who specialises in machine learning and data analysis. Talking to him after his presentation about how ‘big data’ has shifted the emphasis in many university research labs from classic experimental design and data collection, towards a notion of data mining confirmed for me that the vast array of publicly available big datasets means that this modern approach to the scientific method makes novel research a feasible venture for all school students.

Scientific research using a data mining approach is exciting in that the data already exists, replacing the need for laborious experimental testing. The phenomenal progress in the field of artificial intelligence has meant that individual lab-bench experimental datasets are being replaced with enormous datasets which bring with them greater authenticity to the results, and also the ability to explore an expansive array of research questions that were never possible before. Data is amassing quicker than tertiary-level scientists can analyse it, and so the potential for school students to pose innovative research questions of these big datasets is not only boundless, but also a welcome and untapped asset in the quest to answer the world’s most pressing scientific questions.

Scientific method graph
Above: The Scientific Method

Novel research already on the go at WHS

We have already embarked on this exciting journey. Our first venture has been a collaboration with AELTC and IBM, who have kindly provided us with access to a huge dataset from the Wimbledon Tennis Championships. Like all great research groups, and in true STEAM+ style, we bring together different skills. The creative powers of the unclouded vision of the young scientists, supported by our Director of Sport Ms Coutts-Wood’s expertise in sport science and my experience of data analysis, has meant than we are in the final stages of publishing our first scientific paper on the impact of serve speed on winning the point. How apt!

Two more groups started during lockdown. One group under the supervision of Ms McGovern (Head of Chemistry) in collaboration with the University of Bristol, has recently received a special award for their research on Air Pollution. The other group are drawing on the expertise at the European Bioinformatics Institute in Heidelberg, Germany and the Wellcome Trust Genome Campus outside Cambridge. Their research questions range from discovering the differences in proteins associated with immune function in red and grey squirrels, to determining which mammalian species do not have attachment sites for the coronavirus (SARS CoV-2) spike protein. These bioinformatics projects will be launched on the EBI website soon to allow other schools to join in as well. Watch this space!

Just as the new STEAM tower is about to open, so too are new exciting possibilities for our young imaginative scientists at WHS.

Racket Research Club
Above: Discussing exciting new findings in the STEAM tower

 

References

[1] https://magazine.caltech.edu/post/the-most-beautiful-experiment

[2] https://www.nobelprize.org/prizes/chemistry/2020/press-release/

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The positive geographies of Covid-19

Dr. Stephanie Harel, Acting Head of Geography, explores the positive geographies of our current global pandemic, including a stronger local sense of place and a greater environmental consciousness.

As an educator, I concern myself every day with demonstrating how and why “Geography matters”. Central to our discipline, and indeed my own academic interests, is the often-contested concept of ‘place’. At its heart, lies the notion of a meaningful segment of geographical space, although what is also important to understand, is that places are dynamic and multifaceted[1]. Recently, I introduced our Year 12 students to these ideas, as part of the Changing Spaces, Making Places unit in our OCR specification. Over the past three weeks, we have explored the difference between ‘place’ and ‘space’, the characteristics that constitute a place profile and how perception of place can vary depending on factors such as age, gender and personal experience. Lively class debates have discussed how people can see, experience and understand place in different ways and, perhaps most importantly, how our relationships with places can change over time.

I love teaching this unit, because it aligns with my own research interests and allows me to delve into what was the focus of my doctoral thesis. My PhD explored the complexities of people’s emotional response to disasters. Acknowledging that people negotiate their emotions in different ways, my thesis demonstrated the complex ways that emotions influence how the disaster displaced relate to ‘home’ in the aftermath of disaster. As a practitioner, I see much value in using this research to develop students’ understanding of how the concept of place works in practice. During Guided Home Learning, for example, I relished the opportunity to teach a two-week segment as part of the Geography elective for Years 11-13, which explored the ‘Emotional Geographies of Home’. In our sessions, I shared stories from real people who had lost their homes as a result of the 2011 flood event in Brisbane, Australia, and 2011 earthquake in Christchurch, New Zealand. As I explained to my students, the aim of my PhD research was to extend geographic knowledge on the emotional dynamics of natural disasters. However, I also aimed to contribute to debates within our discipline about how places can be disrupted and altered in a myriad of ways and as a consequence of both physical and human processes. Again, these sessions promoted incredibly rich discussions. The level of independent thought and active enquiry shown in students’ post-course reflections showed deep engagement with course content, on both an academic and a personal level; as a teacher, it was richly rewarding to read these reflections.

While my doctoral research was carried out within the context of natural disasters, I believe there is huge potential to explore these ideas further, within our current global climate. Media outlets across the country are presenting the endless disruption caused to places as a result of the COVID-19 global pandemic. This is important, of course; the economic and social consequences of COVID-19 will undoubtedly be severe and long lasting. Still, I would like to intervene amidst what sometimes feels like a barrage of negativity. I want to suggest that there are many positive ways in which the pandemic has altered places around the world, at a variety of different scales. The following, therefore, is what I deem to be ‘The positive geographies of COVID-19’:

A stronger ‘sense of place’

When I was researching in Brisbane and Christchurch, and indeed for my Masters research in the aftermath of Hurricane Katrina[2], one of the positive outcomes of the experience of a natural disaster was the way in which communities came together in the face of crisis. My research exemplified how emotions play a key role in the construction of place and many of my interview narratives demonstrated the value of social capital in the aftermath of catastrophe. Narratives of those who were displaced and subsequently returned to post-earthquake Christchurch, for example, discussed the importance of community support networks and the strengthening of their local neighbourhoods in the aftermath of the earthquake. From what I’ve seen in 2020, the same concepts ring true during a global pandemic.

Above: Hurricane Katrina Flooding, Pixabay

In Geography, a ‘sense of place’ refers to a feeling of belonging; a strong identity that is deeply felt by inhabitants and visitors. It is often a term used by humanistic geographers to describe our attachment to specific locations[3]. I would argue that with communities coming together to clap for NHS carers and networks of volunteers supporting vulnerable members of their communities, lockdown deeply enhanced our local sense of place. It also, I believe, caused us all to redefine our relationship with ‘home’, purely because we spent such an unusually large amount of time there. Socially distanced neighbourhood street parties and road WhatsApp groups where neighbours could check in on each other became the new norm. The 75th anniversary of VE day saw us all aptly enjoying the sound of ‘We will meet again’, celebrating with our local communities, from the comfort of our own driveways. In a personal capacity, lockdown resulted in a significant increase in the amount of time I was able to spend with my husband and young daughter; time I will cherish. I was able to witness my daughter’s first wobbly steps, knowing this was only possible because I was working from home. I then watched her grow confidence as she navigated the potholes along our road, cheered on (from a distance) by our kind neighbours.

Although I have long explored the concept of ‘place’ and acknowledged the way in which places are constructed by humans and human interactions, COVID-19 illuminated this reality in a way I never expected. Places truly are defined by the people within them; it is the experiences we have, and the relationships and memories we create that make geographical locations meaningful. The stronger sense of local place I feel towards my local community is evidence of this, but I am also struck by heightened sense of place created here at school as a result of the pandemic. Despite lockdown, our community remained united – Together Apart – and I think this unwavering sense of place experienced at Wimbledon High School during a time of national crisis is worthy of celebration.

Environmental consciousness

As well as teaching the core Human Geography Unit in Year 12, I also teach our Year 13 Geographers the core Physical systems unit, ‘Earth’s Life Support Systems’. Content within ELSS incorporates an understanding of our global water and carbon cycles, the consequences of human activity on these natural systems and the importance of management strategies which protect our vulnerable planet. Carbon emissions remain one of the world’s most significant environmental concerns. Emerging and developing countries, such as China and India have long been at the top of the contributor list for global greenhouse gas emissions. Interestingly, however, the pandemic has shut down industrial activity and temporarily slashed air pollution levels all around the world.

Above: Pollution levels in China in 2019, left, and 2020. Photograph: Guardian Visuals / ESA satellite data

I find myself wondering: Inadvertently, is this the largest scale pollution experiment the world has ever seen? Could this be the outcome of moving towards a low-carbon, green, economy in the future? And it is not just our dominant developing countries that have seen the positive effects of lower carbon emissions as a result of COVID-induced lockdowns. Italy’s usually heavily congested roads substantially reduced levels of traffic, resulting in drastically lower nitrogen oxide levels in the country[4]. The positive environmental consequences of this are unprecedented and offer an opportunity to think more critically about the implications of our everyday practices.

In addition to the global decline in factory pollution, it is also worthy to acknowledge the positive implications associated with a reduction in air travel as a result of national lockdowns around world. Today’s society is a society (normally) on the move. With the development of mass automobility and aeromobility, the scale of our travel has grown immense, and social life and social organisation are increasingly dependent on mobility[5]. COVID-19, however, has restricted our international mobility in a way that feels almost unnaturally authoritarian. While of course I acknowledge the challenges associated with being bound within our national territories, I’d also like to highlight the positives. The outcome of an inability to travel abroad is an increase in local and national ‘staycations’. I admit that I am someone who has lived in Australia and the USA, but never been to the Peak District. I’ve travelled to Singapore but haven’t explored many of the islands from my Scottish homeland. What COVID-19 has allowed for is an appreciation of the natural beauty that surrounds us not only in locally in London and the South-East, but all over the British Isles. As a nation, our inability to holiday overseas has increased an awareness of our local geographies, prompting an enjoyment of these local landscapes and the wonders that surround us, and sparking a renewed environmental awareness that aims to preserve them.

So then, it is pertinent to remember that 2020 is not a year to write off; perhaps it is, instead, a year full of opportunities. A time to connect and reconnect. A chance to acknowledge the beauty of our local surroundings and reconsider the impact our patterns of consumption so that we can rectify our environmental impact. As a geographer, I have long been fascinated by the relationship between people and places. I hope this post has demonstrated how geographers can offer some very useful ideas for making sense of our current situation; what has happened, what we might be feeling, and how we might go forward – stronger than before.

References:

[1] Cresswell, T. (2004) Place: A short introduction. Blackwell Publishing

[2] Morrice, S. (2012) Heartache and Hurricane Katrina: Recognising the influence of emotion in post-disaster return decisions. Area 45(1), 1-7.

[3] Massey, D. (2005). For Space. London: Sage.

[4] Watts, J. & Kommenda, N. (2020) Coronavirus pandemic leading to huge drop in air pollution. Accessed at: https://www.theguardian.com/environment/2020/mar/23/coronavirus-pandemic-leading-to-huge-drop-in-air-pollution

[5] Gustafan, P. (2014) Place attachment in an age of mobility. In Manzo and Devine-Wright Place (eds.) attachement: Advances in Theory, Methods and Application. Routledge, 2014.

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What are the links between romance languages and music?

Matilda, Year 13, investigates the links between romance languages and music to discover whether the learning of one can help in the understanding of the other.

Music and language

It is often said that music is the ‘universal language of mankind’, due to its great expressive powers which have the ability to convey sentiments and emotions.

But what are the connections between music and languages?

A romance language is a language derived from Latin and this group of languages has many similarities in both grammar and vocabulary. The 5 most widely spoken romance languages are Spanish (with 470 million speakers), Portuguese, French, Italian and Romanian.

There are 3 main connections between languages and music:

 

The first of these is the role of melody in recall:

There is a link between languages and music in remembering words. This is shown in a study where words were better recalled when learned as a song rather than a speech. This is because melody and rhythm give the memory cues to help recall information.[1]

Language, music, and emotion:

The British anthropologist and evolutionary psychologist who specialises in primate behaviour, Robin Dunbar, says that music and language help to knit people together in social groups. This is because musicians process music as a language in their heads. Studies have shown the planum temporal in the brain is active in all people whilst listening to music.

However, in non-musicians, the right-hand side was the most active, meanwhile, in musicians, the left side dominated, this is the side believed to control language processing. This shows that musicians understand music as a language in their brain.

In another study, scientists analysed the Broca’s area, which is crucial in language and music comprehension. It is also responsible for our ability to use syntax. Research has shown the in the Broca’s area of the brain, musicians have a greater volume of grey matter, suggesting that it is responsible for both speech and music comprehension.

The relationship between music and languages:

Brain and Languages Both music and languages share the same building blocks as they are compositional. By this, I mean that they are both made of small parts that are meaningless alone but when combined can create something larger and meaningful.

For example, the words ‘I’, ‘love’ and ‘you,’ do not mean much individually, however, when they are constructed in a sentence, carry a deep sentimental value. This goes the same for music notes, which when combined can create a beautiful, purposeful meaning.

Musical training has been shown to improve language skills.[2] In a study carried out in 2011, developmental psychologists in Germany conducted a study to examine the relationship between development of music and language skills. In the experiment, they separated children aged 4 into 2 groups, 1 of these groups receiving musical training, and one did not.

Later on, they measured their phonological ability (the ability to use and manipulate language) and they discovered the children who had received music lessons were better at this. Therefore, this shows that learning and understanding language can go hand in hand with musical learning and ability.

–

References: 

[1] See https://www.theguardian.com/teacher-network/2018/mar/14/sound-how-listening-music-hinders-learning-lessons-research
[2] See https://www.psychologytoday.com/intl/blog/the-athletes-way/201806/how-does-musical-training-improve-language-skills

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Nanotechnology and its future in medicine – 07/09/18

Maya (Year 11), discusses the uses of nanotechnology in medicine, thinking about how far it has come and helped doctors. She also considers the dangerous aspects of using such small technology and the future benefits it may bring.

Technology in medicine has come far and with it the introduction of nanotechnology. Nanotechnology is the action of manipulating structures and properties at an atomic and molecular level as the technology is so small; it being one-billionth of a metre. This technology has many uses such as electronics, energy production and medicine and is useful in its diverse application. Nanotechnology is useful in medicine because of its size and how it interacts with biological molecules of the same proportion or larger. It is a valuable new tool that is being used for research and for combatting various diseases.

In medicine, nanotechnology is already being used in a wide variety of areas, the principle area being cancer treatment. In 2006 a report issued by NanoBiotech Pharma stated that developments related to nanotechnology would mostly be focused on cancer treatments. Thus, drugs such as Doxil, used to treat ovarian cancer will use nanotechnology to evade and surpass the possible effects of the immune system enabling drugs to be delivered to the disease-specific areas of the body. Nanotechnology is also helping in neuroscience where European researchers are currently using the technology to carry out electrical activity across dead brain tissue left behind by strokes and illnesses. The initial research was carried out to get a more in-depth analysis of the brain and to create more bio-compatible grids (a piece of technology that surgeons place in the brain to find where a seizure has taken place). Thus, it is more sophisticated than previous technologies which, when implanted, will not cause as much damage to existing brain tissue.

Beyond help in combatting cancer and research, nanotechnology is used in many areas in medicine from appetite control to medical tools, bone replacement and even hormone therapy. Nanotechnology is advancing all areas of medicine with Nano-sized particles enhancing new bone growth and additionally, there are even wound dressings that contain Nano-particles that allow for powerful microbial resistance. It is with these new developments that we are revolutionising the field of medicine, and with more advancements, we will be able to treat diseases as soon as they are detected.

Scientists are hoping that in the future nanotechnology can be used even further to stop chemotherapy altogether; fighting cancer by using gold and silica particles combined with nanotechnology to bind with the mutated cells in the body and then use infra-red lasers to heat up the gold particles and kill the tumour cells. This application would be beneficial as it would reduce the risk of surrounding cells being damaged as the laser would not affect them as much as the chemotherapy would.

In other areas, nanotechnology is further developing with diagnostics and medical data collection. This means that by using this technology, doctors would be able to look for the damaged genes that are associated with particular cancers and screen the tumour tissue faster and earlier than before. This process involves the Nano-scale devices being distributed through the body to detect chemical changes. There is also an external scan by use of quantum dots on the DNA of a patient which is then sequenced to check if they carry a particular debilitating genome, therefore providing a quicker and easier method for doctors to check in detail if a patient has contracted any illnesses or diseases. Furthermore, doctors will be able to gain a further in-depth analysis and understanding of the body by use of nanotechnology which surpasses the information found from x-rays and scans.

While this is a great start for nanotechnology, there is still little known about how some of the technology might affect the body. Insoluble nanotechnology for example, could have a high risk of building up in organs as they cannot diffuse into the bloodstream. Or as the nanoparticles are so small, there is no controlling where they could go, which might lead to Nano-particles entering cells and even their nuclei, which could be very dangerous for the patient. The science and technology committee from the House of Lords have reported concerns about nanotechnology on human health, stating that sufficient research has not been conducted on “understanding the behaviour and toxicology of nanomaterials” and it has not been given enough priority especially with the speed at which nanotechnology is being produced.

Nanotechnology is advancing medical treatment at a rapid rate, with new innovative technologies approved each year to help combat illnesses and diseases. Whilst more research needs to be conducted, the application of Nano-medicine will provide a platform of projected benefits that has potential to be valuable. Overall with the great burden that conditions like cancer, Alzheimer’s, HIV and cardiovascular diseases impose on the current healthcare systems, nano-technology will revolutionise healthcare with its advances techniques in the future as it progresses.

@Biology_WHS ‏